The Russian politics saw the reindustrialization the restoration of the industrial base using new technological means. This path can serve as a new direction in finding a source of economic growth. This article aims to determine the degree of regional reindustrialization and the impact of various factors on it. Achieving this goal required an analysis of the factors influencing the growth of GRP using a model of the impact of these factors on the region’s reindustrialization. The obtained model confirms that the most significant increase in GRP happened in the regions focused on post-industrial factors of development. Further analysis shows that all the subjects of the Tyumen Region employ the strategy of increasing fixed capital as a factor of GRP growth. Thus, the authors conclude that the Tyumen Region is still on its way to the knowledge economy. The shift to the post-industrial stage of development requires performing a number of measures aimed at the development of the productive forces of the region, which would allow the further transition to the post-industrial (or digital) economy